I've said it before and no doubt will again. Virtually any game is possible in Game Guru, if you can script. I've done a 2D shooter in the past, plus a Space Harrier type demo ( never released or shown it as it was unfinished, but the main engine worked okay ) I've even started a map editor in the past. An RTS in 2D would be possible (it may even be possible to use 3D in honesty). However, only if you can script it in it's entirety. You will be using practically no Game Guru features and everything would have to be controlled by you. So the answer is probably no - unless you can code an RTS in another coding language, in which case you can probably code it in GG.
SPECS: Q6600 CPU. Nvidia 660GTX. 8 Gig Memory. Win 7.