I've seen this, I spent hours removing items and such, changing settings to get speed back. Then I loaded in an older map, but not really much different to the one I had been tweaking. It ran fine. Something had caused a huge loss of frame rate in the old map. Even after removing many item's and having a lot less populated map it ran badly. The old one had more stuff and ran back at 60 fps which was my original goal, rather than the 30 odd it had dropped down to.
It's a weird one, but definitely can happen, and can kill your map if you don't have a backup or notice a difference as in the above post. I think it is a bug, a really nasty bug, but difficult to notice. I imagine a few people have encountered it but simply put it down to GG being slow. Something seems to hog resources badly when it happens, even dropping down to lowest shaders didn't help much for me at the time.
SPECS: Q6600 CPU. Nvidia 660GTX. 8 Gig Memory. Win 7.