Yes... As long as it isn't some MMO spin-off I'll be happy. I am really hoping they add vehicles in 4... we had a pseudo car in FO2 and cool vehicles in Tactics and BOS... about time we get them in the 3D universe and would help them compete with MadMax.
The addition of hardcore mode in NV was such a big step towards bringing the 3D universe in line with the 2D universe and I would love to see them fill in the remaining gaps.
Hopefully it will be set in the Noth-West U.S. or somewhere less dull than the Mojave was.
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